RESEARCHERS (M-Z)

Brian MacVicar

Professor, University of British Columbia

Collaborator

Dr. MacVicar is the Co-Director of the Djavad Mowafaghian Centre for Brain Health at the University of British Columbia. He holds the Canada Research Chair in Neuroscience at UBC and is Professor and Head, Basic Neuroscience, in the Department of Psychiatry.

Dr. MacVicar’s research has focused on the mechanisms required to maintain a healthy brain by finding ways to prevent neuronal damage. His work has provided new insights into potential targets for preventing brain damage via neuronal death during stroke.

Dr. MacVicar has been a leader in the development and application of advanced brain imaging techniques during his career. He discovered that brain tissue is more transparent in infrared wavelengths, which are used widely to visualize nerve cells in intact brain tissue. With Image Science, a company he founded, he developed software that was widely used to control scientific image acquisition equipment and imaging analysis. The MacVicar lab has implemented two-photon microscopy and uncaging techniques to investigate and visualize complex interactions in the brain. The application of advanced imaging techniques has allowed his lab to make significant contributions to our understanding of how neuronal activity is regulated and how to protect nerve cells during stroke.

Dr. MacVicar is a Fellow of The Royal Society of Canada (FRSC) and of The Canadian Academy for Health Sciences (FCAHS).

MacVicar Lab
Djavad Mowafaghian Centre for Brain Health
4th Floor, 2215 Wesbrook Mall
Vancouver BC, V6T 2B5
Tel: 604-822-7797
brian.macvicar@ubc.ca
Website

Anne Marinier

Associate Professor, Université de Montréal

Collaborator

Dr. Marinier is an Associate Professor in the Department of Chemistry at the Université de Montréal, and Principal Investigator and Director of Medicinal Chemistry at the Institute for Research in Immunology and Cancer (IRIC).

Dr. Marinier and her group focus on medicinal chemistry. They work to design and synthesize new chemical entities with proven biological and therapeutic activity in the treatment of cancer and other related diseases.

Trained as a Chemist, Dr. Marinier earned her Ph.D. in Synthetic Organic Chemistry at the Université de Sherbrooke in 1990 after working under the guidance of Pierre Deslongchamps. She then joined Garland Marshall’s team at Washington University School of Medicine, in St. Louis, for a postdoctoral fellowship.

She was hired by pharmaceutical company Bristol-Myers Squibb in 1991. There she worked on developing new anti-infective, anti-inflammatory and anti-tumor drugs. She joined IRIC in 2007 and contributed to the creation of what would become the country’s largest medicinal chemistry core facility in a university setting.

NMIN project involvement:

Collaborator: Neutrophil encapsulation platform for targeted drug delivery

Pavillon Marcelle-Coutu, 4306-9
2950 Chemin de Polytechnique
Montreal, Quebec H3T 1J4
Tel: 514-343-6111 ext. 17351
anne.marinier@umontreal.ca
Website

John Marshall

Professor, University of Toronto

Collaborator

Dr. Marshall is a Professor of Surgery at the University of Toronto, an intensivist at St. Michael’s Hospital, and a Senior Investigator in the Keenan Research Centre for Biomedical Science.

His laboratory studies the cellular mechanisms underlying prolonged neutrophil survival in trauma and sepsis. As a clinical investigator he has been the principle investigator of the AATICC trial of empiric antibiotic therapy for suspected ICU-acquired infection and of the CHAT trial of adjuvant therapy for H1N1 influenza, as well as a co-investigator on a number of Trials Group programs. He has also been a steering committee member for a number of industry-sponsored trials of novel therapies for sepsis.

He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of 37 investigator-led critical care clinical research groups and vice-chair of the International Severe Acute Respiratory and Emerging Infections Consortium.

He has given more than 1000 invited lectures at more than 500 meetings around the world, has published more than 475 manuscripts and book chapters, has been cited more than 100,000 times, and is an Associate Editor of the journals Critical Care Medicine and Critical Care.

NMIN project involvement:

Collaborator: Neutrophil encapsulation platform for targeted drug delivery

St. Michael’s Hospital
Room 4-007, 30 Bond St
Toronto, ON, M5B 1W8
Tel: 416-864-5225
marshallj@smh.ca
Website

Anton McCaffrey

Sr. Director, TriLink BioTechnologies

Collaborator

Dr. McCaffrey is Senior Director of Emerging Science and Innovation at TriLink BioTechnologies.

Dr. McCaffrey is a researcher in the area of nucleic acid therapeutics and diagnostics, with expertise in design, manufacturing and purification of messenger RNA (mRNA) at gram scales for gene therapy applications, RNA interference, zinc-finger nucleases, TALENs, CRISPR and microRNAs. He has over 25 years experience designing nucleic acid-based therapeutics. His research interests include scalable mRNA manufacturing processes, chemical modification of mRNA to reduce innate immune stimulation, and development of specialized assays for mRNA characterization.

Michel Meunier

Professor, Polytechnique Montréal

Researcher

Dr. Michel Meunier is a professor in the Department of Engineering Physics and the head of the Laser Processing and Plasmonics Laboratory, at Polytechnique Montréal.

Dr. Meunier’s team has developed a new approach to synthesis of gold-silver alloy nanomaterials, with fine control of their composition and size, and is working on the development of novel medical imaging techniques. Dr. Meunier has perfected a technique for detection of cell-surface biomarkers that is a cost-efficient improvement over the classic immunofluorescence method: 3D multiplexed immunoplasmonics microscopy, which uses Abs-functionalized plasmonic nanoparticles (fNPs) as “headhunters” to target biomarkers, with reflected light microscopy (RLM) used to detect the biomarkers visually.

Dr. Meunier is also developing tools for cancer treatment, drug delivery, and nanosurgery, such as the “light nanoscalpel” which is aimed at functionalized plasmonic nanoparticles that concentrate its light to perforate the membrane. Recently, Dr. Meunier designed a procedure for optimized, controlled design (material, shape and size) of metallic nanoparticles to improve nanosurgery performance.

Robert Molday

Professor, University of British Columbia

Collaborator

Dr. Molday is a Professor of Biochemistry and Molecular Biology and of Ophthalmology and Visual Sciences, a Canada Research Chair in Vision & Macular Degeneration, Director of the Centre for Macular Research, and Senior Member of the Brain Research Centre at the University of British Columbia.

He has elucidated the molecular and cellular mechanisms underlying a number of retinal diseases including X-linked retinoschisis, retinitis pigmentosa, Stargardt macular degeneration, and Lebers Congenital Amaurosis. He has used this information to develop therapeutic treatments for a number diseases in animal models for retinal diseases. These include gene and drug based therapies.

Research in his laboratory is currently directed toward identifying and characterizing vertebrate retinal photoreceptor proteins and elucidating their role in: phototransduction and other signaling pathways; rod and cone photoreceptor cell structure and morphogenesis; lipid transport across membranes; protein and vesicle trafficking; and inherited retinal degenerative diseases which are a leading cause of blindness in the world. His lab is also involved in drug discovery and gene therapy as potential therapeutic treatments for inherited retinal degenerative diseases including macular degeneration and retinitis pigmentosa.

Life Sciences Centre
2350 Health Sciences Centre
The University of British Columbia
Vancouver, BC V6T 1Z3
Tel: 604–822–6173
molday@mail.ubc.ca
Website

Neeloffer Mookherjee

Associate Professor, University of Manitoba

Researcher

Dr. Mookherjee is an Associate Professor at The University of Manitoba, Canada, within the departments of Internal Medicine and Immunology, and the section of Proteomics and Systems Biology.

Dr. Mookherjee’s research program is focused on understanding the molecular mechanisms underlying chronic inflammation. Her research group seeks to understand the role of cationic host defence peptides (also known as antimicrobial peptides) in the biological process of inflammation and innate immunity.

Her research group employs various Systems Biology approaches to interrogate the regulatory mechanisms underlying the bioactivity of these peptides. She is also pursuing the use of small cationic peptides as an immunomodulatory therapy for chronic inflammatory diseases such as arthritis and asthma.

She is also involved in a collaborative initiative to define molecular changes in human lung and blood following inhaled exposure to environmental air pollutants such as diesel exhaust.

Dr. Mookherjee is current Chair of WISDOM (Women In Science: Development, Outreach & Mentoring), a Rady Faculty of Health Sciences instituted initiative at The University of Manitoba.

NMIN project involvement:

Co-Investigator: Nanoparticle formulations for anti-inflammatory IDR peptides

University of Manitoba
799 JBRC, 715 McDermot Ave.
Winnipeg, MB R3E 3P4
Tel: 204-789-3835
neeloffer.mookherjee@umanitoba.ca
Website

Brad Nelson

Professor, University of Victoria

Researcher

Dr. Nelson is Distinguished Scientist and Director of the Deeley Research Centre at the BC Cancer Agency, Scientific Co-Director of BC Cancer's Immunotherapy Program, Professor of Biochemistry/Microbiology at the University of Victoria, and Professor of Medical Genetics at the University of British Columbia.
Dr. Nelson became founding Director of the Deeley Research Centre in 2003. His laboratory is pursuing the development of innovative immunotherapies for cancer. Areas of focus include: understanding how tumour-reactive T cells and B cells promote survival of cancer patients; using genomic and bioinformatic methods to decipher the barriers to effective immunotherapy; and using the power of genetic engineering to create more precise and potent immune cells for use in immunotherapy.

Deeley Research Centre
BC Cancer – Victoria
2410 Lee Avenue, 3rd Floor
Victoria, BC, V8R 6V5
Tel: 250-519-5705
bnelson@bccrc.ca
Website

Timothy Nichols

Professor, University of North Carolina

Collaborator

Dr. Nichols is a Professor of Medicine and Pathology in the Division of Cardiology, and Director of the Francis Owen Blood Research Laboratory at the University of North Caroina - Chapel Hill.

As an internationally recognized clinical investigator, Dr. Nichols’ current research focuses on improving treatments for patients with inherited bleeding disorders. His expertise in vascular biology research focuses on the role of von Willebrand factor in arterial thrombosis.

Dr. Nichols also has an active hemostasis research program to develop new therapies for hemophilia A and hemophilia B, especially those complicated by inhibitory antibodies (anti-drug antibodies).

Dr. Nichols’ other special interests include coronary artery disease and thrombosis, cardiac catheterization, coronary angioplasty, and novel ultrasound imaging techniques.

CB #3114 Chapel Hill, NC 27599 USA
Tel: 919-966-1360 tnichols@med.unc.edu Website

Mark Nitz

Professor, University of Toronto

Researcher

Dr. Nitz is a professor of Chemistry at the University of Toronto. His research focuses on using organic synthesis coupled with the power of biocatalysis and state of the art biophysical techniques such as fluorescence, NMR, mass spectrometry, and microcalorimetry, to creatively assemble new tools for studying biology.

His current research is in the area of glycosaminoglycan (GAG) chemistry and biology. By understanding the underlying biology and learning new techniques to synthesize and manipulate this interesting class of natural products, his lab hopes to learn new ways of intervening in a wide variety of human diseases.

DB 459 – Lash Miller Chemical Laboratories
80 St. George Street
Toronto, ON, M5S 3H6
Tel: 416-946-0640
mnitz@chem.utoronto.ca
Website

Keith Pardee

Assistant Professor, University of Toronto

Researcher

Dr. Pardee is Assistant Professor at the Leslie Dan Faculty of Pharmacy and Canadian Research Chair (tier II) in Synthetic Biology and Human Health at the University of Toronto.

Dr. Pardee's research focuses on moving synthetic biology outside of the cell. His research program combines biochemistry, molecular engineering, and electronics to create a new class of sterile and abiotic tools for applications both in and outside the lab. By generating in vitro synthetic biology programs and creating in vitro environments to host these biomolecular programs, he aims to produce small, programmable sensors and devices for research, portable diagnostics, implantable therapeutics, and tools for regenerative medicine and tissue engineering.

Dr. Pardee’s research has been published in Cell, Nature, PLoS Biology, and Genes and Development, among other journals.

Leslie Dan Faculty of Pharmacy University of Toronto 144 College Street Toronto, Ontario, M5S 3M2 Tel: 416-946-5289 keith.pardee@utoronto.ca
Website

Victor Rafuse

Professor, Dalhousie University

Collaborator

Dr. Rafuse seeks to adapt what we know about the developing nervous system to help treat neurodegenerative diseases and conditions such as spinal cord injury, ALS, and Parkinson’s disease. Using molecular biology, electrophysiology and standard anatomical immunohistochemistry (as well as in vitro and in vivo techniques), Dr. Rafuse is working towards understanding how motor axons grow and form stable synapses during development and following nerve injury.

Dr. Rafuse is well known for engineering adult human stem cells into functional motor neurons, for use in drug-screening models and potential future therapies for ALS. He and his team were also able to induce the axons of motor neurons to make appropriate nerve-to-muscle connections after a peripheral nerve injury.

Dr. Rafuse is also working on a gene therapy to help people with ALS breathe more easily, and launching new projects to explore the relationship between metabolism and ALS.

Department of Medical Neuroscience, Dalhousie University
Neural Development & Plasticity Laboratory
3rd floor, Life Science Research Institute
1348 Summer Street
Halifax, NS B3H 1X5
Tel: 902-494-3609
victor.rafuse@dal.ca
Website

Arun Raturi

CSO, Entos Pharmaceuticals

Collaborator

Dr. Raturi is Chief Scientific Officer at at Entos Pharmaceuticals. He leads the development of the Entos Fusogenix platform. He has considerable experience in the development and characterization of pharmaceutics and biologics, with more than 6 years of industry experience in various roles.

His expertise is in the use of nanoparticle-based novel platforms for the targeted delivery of genes, small molecules and bio-therapeutics for cancer therapy and anti-aging. Specifically, he specializes in targeted in-vivo delivery of non-toxic liposomal formulations of miRNA, mRNA, SiRNA, DNA and crisper.

Dr. Raturi trained at The Scripps Research Institute in La Jolla, CA, and holds a Ph.D. in biochemistry from the University of Windsor.

Thomas Redelmeier

Founder, CEO & President, Cuprous Pharmaceuticals

Researcher

Dr. Redelmeier has more than 30 years of experience studying lipid nanoparticle systems including 20 years at Transferra where he was involved with more than 30 programs that were in preclinical and/or clinical development. He completed his PhD studies at the University of British Columbia, working with Dr. Pieter Cullis. He is the author of more than 25 peer reviewed papers, and has co-authored a book on Percutaneous Absorption.

Dr. Redelmeier was previously President & CEO of Transferra Nanosciences (formerly known as Northern Lipids). He led the company for 20 years, transforming it into a leader in the provision of Contract Research/Manufacturing services specifically related to lipid nanoparticle formulations of active pharmaceutical ingredients. The company was sold to EVONIK in 2016, where it continues to be active in this area.

Gregor Reid

Professor, Western University

Collaborator

Dr. Reid is a Distinguished Professor of Microbiology and Immunology and Surgery at Western University, and the Endowed Chair in Human Microbiome and Probiotics at the Lawson Health Research Institute. Dr. Reid’s research interests include: Microbiome and probiotics, Women's health, Environmental influences on health, and genitourinary infections.

Having been a pioneer of probiotic research and the study of microbes in the urogenital tract of women, his research has expanded to studies of the gut, breast, heart and use of probiotics to detoxify environmental pollutants.

Dr. Reid’s research primarily focuses on beneficial microbes, and he is one of the world’s foremost experts on probiotics. To date, he has developed novel probiotic therapies used by several million people around the world and has held 28 patents.

Raymond Reilly

Professor, The University of Toronto

Researcher

Dr. Reilly’s research focuses on developing novel radiopharmaceutical agents to detect and treat cancer. His work involves discovery, preclinical development and clinical translation of these agents for molecular imaging or molecularly targeted radiotherapy of cancer.

Dr. Reilly’s research group develops and studies the use of novel radiopharmaceutical probes that target proteins overexpressed on tumour cells to aid in cancer diagnosis, imaging and treatment.

Dr. Reilly’s group investigates monoclonal antibodies labeled with radioisotopes for imaging and treatment of cancer, and is also studying the use of radiolabelled gold nanoparticles for locally treating tumours with radiation. In one unique approach, the antibodies or nanoparticles are designed to enter tumour cells and deliver a short range radiation called Auger electrons inside the cell rather than from the outside, reducing the toxicity to nearby healthy tissues.

Prof. Reilly’s group aims to translate their most successful imaging and radiotherapeutic agents to clinical trials. They evaluate the agents preclinically using animal tumour models and develop pharmaceutical quality formulations of the agents that are ready to test in phase I clinical trials.

Room 1204
Leslie Dan Faculty of Pharmacy
University of Toronto
144 College Street
Toronto ON M5S 3M2
Tel: 416-946-5522
raymond.reilly@utoronto.ca
Website

Colin Ross

Associate Professor, The University of British Columbia

Researcher

Dr. Colin Ross is Associate Professor in the Faculty of Pharmaceutical Sciences at the University of British Columbia, and a Scientist at BC Children’s Hospital.

Dr. Ross’s expertise spans pharmacogenetics, genomics, drug development, drug safety, adverse drug reactions, predictive genetics, and genetic/clinical factors of drug response. Ross Lab researchers investigate the genetic basis of disease and severe adverse drug reactions using genomics-guided precision medicine approaches to help make drugs safer, improve disease diagnosis, and develop new, targeted therapeutics.

Dr. Ross’s research capitalizes upon national and international collaborations with clinicians, researchers and industry partners. He was instrumental in the establishment of the Canadian Pharmacogenomics Network for Drug Safety (CPNDS), a nation-wide collaborative network of researchers. He currently holds a leadership role on the network’s executive steering committee.

Fabio Rossi

Professor, The University of British Columbia

Researcher

Dr. Fabio Rossi is Professor in the Department of Medical Genetics at the University of British Columbia (UBC), Director of the UBC Biomedical Research Centre, and a Board member of the NCE Stem Cell Network.

Dr. Rossi's research focuses on stem cells, regeneration, gene therapy, and control of cell fate. He has provided seminal contributions to multiple fields related to the role of inflammation and mesenchymal progenitors in adult tissue regeneration and pathogenesis. His laboratory was the first to show that microglia (CNS-resident macrophages) are self-renewing locally and do not originate form bone marrow. He also described a dramatic and unexpected positive trophic role of tissue resident mesenchymal progenitors in tissue regeneration, starting a novel and very active new field investigating these cells.

Biomedical Research Centre (BRC)
UBC Campus
2222 Health Sciences Mall
Vancouver, BC V6T 1Z3
Tel: 604–822–7138
fabio@brc.ubc.ca
Website

Manish Sadarangani

Director, Vaccine Evaluation Center & Assistant Professor, UBC

Collaborator

Dr. Sadarangani is director of the Vaccine Evaluation Center at the BC Children’s Hospital Research Institute and assistant professor in the Division of Infectious Diseases, UBC Department of Pediatrics. He completed his Doctor of Philosophy with the Oxford Vaccine Group in the UK, developing novel vaccine candidates for protection against capsular group B meningococcal disease, and completed a Fellowship in Pediatric Infectious Diseases in Vancouver in 2013 before returning to Oxford to work as a Pediatric Infectious Diseases physician. He has worked in pediatrics throughout the world, including in sub-Saharan Africa, Asia, Australia, North America and Europe.

Dr. Sadarangani’s research links clinical trials with basic microbiology, immunology and epidemiology to address clinically relevant problems related to immunization and vaccine-preventable diseases. Specific research interests include meningococcal disease, bacterial vaccines, understanding vaccine-induced immunity via systems biology, meningitis and encephalitis, maternal immunization, the microbiota and antibiotic resistance.

NMIN project involvement:

Collaborator: COVID-19 Therapeutics

Ramona Salvarinova

Clinical Assistant Professor, The University of British Columbia

Researcher

Dr. Salvarinova is a Clinical Assistant Professor in the Divison of Biochemical Diseases of the Department of Pediatrics, within the Faculty of Medicine at the University of British Columbia.

She works as a full-time physician with the Division of Biochemical Diseases at BC Children’s Hospital and provides care for pediatric patients diagnosed with inborn errors of the metabolism, as well as pediatric metabolic consultative services within British Columbia. She has interest in innovative treatments for patients with rare diseases and is investigator or co-investigator in several clinical trials.

Dr. Salvarinova is a fellow with the Royal College of Physicians and Surgeons of Canada and the Canadian College of Medical Geneticists.

Przemyslaw (Mike) Sapieha

Associate Professor, University of Montreal

Researcher

Dr. Sapieha is the director of the Neurovascular Eye Disease Lab at the Maisonneuve-Rosemont Hospital Research Centre and holds the Wolfe Professorship in translational vision research and a Canada Research Chair in retinal cell biology. He is an associate professor in the departments of Ophthalmology and Biochemistry at the University of Montreal and an adjunct professor of Neurology and Neurosurgery at McGill University. He is also the Founder and Chief Scientific Officer of SemaThera Inc.

His research team has made impactful discoveries about the mechanisms underlying age and diabetes-related loss of vision, implicating deregulation of neuronal metabolism and cellular senescence in retinal vascular diseases such as diabetic retinopathy; notably, they identified roles for guidance cues such as Semaphorins and Netrins in these diseases.

Dr. Sapieha’s important contributions to the understanding of the mechanisms underlying retinal disease have led to new avenues of treatment to prevent blindness and made him a leader in his field.

Université de Montréal
PO Box 6128, Centre-ville Station
Montréal, Québec H3C 3J7
Tel: 514-252-3400 ext 7711
mike.sapieha@umontreal.ca
Website

Edward Sargent

Professor, The University of British Columbia

Collaborator

Dr. Sargent is University Professor in the Edward S. Rogers Sr. Department of Electrical and Computer Engineering at the University of Toronto. He holds the Canada Research Chair in Nanotechnology and also serves as Vice President - International. He is founder and CTO of InVisage Technologies Inc. of Menlo Park, and a co-founder of Xagenic Inc. of Toronto.

Professor Sargent’s research interests cover many areas of nanotechnology and its application to communications and computing, medicine, and tapping new energy sources.His research has been cited more than 16,000 times and has been disseminated in Nature, Science, Nature Materials, Nature Nanotechnology, Nature Chemistry and Nature Photonics. His book The Dance of Molecules: How Nanotechnology is Changing Our Lives (Penguin) was published in Canada and the United States in 2005 and has been translated into French, Spanish, Italian, Korean, and Arabic.

GB 447
10 King’s College Road
Toronto, Ontario M5S 3G4
Tel: 416-946-5051
ted.sargent@utoronto.ca
Website

Molly Shoichet

Professor, The University of British Columbia

Collaborator

Dr. Shoichet is an expert in the study of polymers for drug delivery and tissue regeneration. She holds the Tier 1 Canada Research Chair in Tissue Engineering and is Professor of Chemical Engineering & Applied Chemistry and Biomaterials & Biomedical Engineering at the University of Toronto.

Dr. Shoichet aims to advance the basic science and enabling technologies of tissue engineering and drug delivery. She is a world leader in the areas of polymer synthesis, biomaterials design and drug delivery in the nervous system. Her research program is unique in its breadth, focusing on strategies to promote tissue repair after traumatic spinal cord injury, stroke and blindness and enhance both tumour targeting through innovative strategies and drug screening via 3D cell culture with new hydrogel design strategies.

Dr. Shoichet has founded three spin-off companies and is actively engaged in translational research with several industry partners and in science outreach.She is currently Senior Advisor on Science & Engineering Engagement at U of T and serves on the Board of the Ontario Science Centre.

Dr. Shoichet is the recipient of 44 prestigious national and international awards. She is the only person ever to be inducted into all three of Canada’s National Academies. In 2011, Dr. Shoichet was appointed to the Order of Ontario, Ontario’s highest civilian honour. In 2013, her contributions to Canada’s innovation agenda and the advancement of knowledge were recognized with the QEII Diamond Jubilee Award.

Donnelly Centre for Cellular & Biomolecular Research
160 College Street, Room 514
Toronto, Ontario M5S 3E1
Tel: 416-978-1460
molly.shoichet@utoronto.ca
Website

Elizabeth Simpson

Professor, The University of British Columbia

Collaborator

Dr. Simpson is a leading scientist in mammalian genetics and genomics. The overall goal of her research is to improve treatment for human disorders of the central nervous system, with a focus on brain and eye.

At the University of British Columbia, she is a Senior Scientist at the Centre for Molecular Medicine and Therapeutics (CMMT), a Professor in the Department of Medical Genetics, and an Associate Member in the Departments of Psychiatry and Ophthalmology & Visual Sciences. She is also an Investigator of the Centre for Brain Health and a Founding Fellow of the Institute of Mental Health. She currently serves as Director of the CMMT Mouse Animal Production Service.

Dr. Simpson is best known for her work on mouse models of human disease, and has identified a gene implicated in bipolar disorder (manic-depressive illness). Currently, she and her laboratory are working on the development of gene-based delivery of proteins; also known as “gene therapy”.

Centre for Molecular Medicine and Therapeutics (UBC) at Child & Family Research Institute
3020 – 950 West 28th Avenue
Vancouver, BC V5Z 4H4
Tel: 604-875-3850
simpson@cmmt.ubc.ca
Website

Shiela Singh

Professor, McMaster University

Collaborator

Dr. Singh is a professor of surgery and biochemistry, chief pediatric neurosurgeon at McMaster Children’s Hospital, prior Division Head of Neurosurgery at Hamilton Health Sciences, and scientist appointed to the Stem Cell and Cancer Research Institute at McMaster University. She holds a Tier 1/Senior Canada Research Chair in Human Brain Cancer Stem Cell Biology, and is Director of the McMaster Surgeon Scientist Program. She is also CEO and a co-founder of Empirica Therapeutics.

Dr. Singh’s lab applies a developmental neurobiology framework to the study of brain tumorigenesis. Building upon previous cell culture techniques developed for the isolation of normal neural stem cells (NSC) and applying them to brain tumours, and through development of a xenograft model to efficiently study brain tumour initiating cell (BTIC) activity, Dr. Singh’s lab aims to understand the molecular mechanisms that govern BTIC self-renewal. Dr. Singh is currently studying the regulation of BTIC signaling pathways in glioblastoma, brain metastases and childhood medulloblastoma, with an ultimate goal of selectively targeting the BTIC with appropriately tailored drug and molecular therapies.

NMIN project involvement:

Collaborator: Neutrophil encapsulation platform for targeted drug delivery

MDCL 5027
McMaster University
1280 Main Street West
Hamilton, Ontario L8S 4L8
ssingh@mcmaster.ca
Website

Terrance Snutch

Professor, The University of British Columbia

Collaborator

Dr. Snutch is a Professor in the Department of Psychiatry, Faculty of Medicine, in the Department of Zoology, Faculty of Science, and in Michael Smith Laboratories at the University of British Columbia. He hold a Canada Research Chair in Biotechnology and Genomics-Neurobiology, and is Director of Translational Neuroscience in the Djavad Mowafaghian Centre for Brain Health.

His lab’s major research interest is the study of the molecular mechanisms of signal transduction in the nervous system and its relationship to neurological disorders. The research utilizes a multidisciplinary approach to characterize various aspects of the molecular, electrophysiological, pharmacological, biochemical and genetic properties of ion channels in normal and pathophysiological states.

His current projects involve epilepsy, migraine, schizophrenia, autism and chronic pain. The lab also employs state-of-the-art 3rd generation sequencing (MinION) aimed at defining genetic and epigenetic disease-related states. Dr. Snutch actively translates discoveries to industry and patients and to date, has designed and advanced new drugs for pain and epilepsy into the clinic.

#301 – 2185 East Mall
Vancouver, BC V6T1Z4
Tel: 604-822-6968
snutch@msl.ubc.ca
Website

Chris Tam

Co-Founder & CEO, Integrated Nanotherapeutics

Collaborator

Dr. Tam is co-founder of Integrated Nanotherapeutics. She obtained her B.Sc. in Biochemistry from McGill University and her Ph.D. in Cell Biology from the University of Alberta. She has extensive research experience in biochemistry, cell biology as well as drug design and development.

Prior to founding Integrated Nanotherapeutics, Dr. Tam worked at the Life Sciences Institute at the University of British Columbia, where she was part of the supervisory team for graduate and post-graduate scientists working on the development of lipid nanoparticles for the delivery of macromolecule drugs, such as siRNA and DNA, as well as small molecule drugs. Many of these lipid nanoparticle drug formulations have direct implication for the treatment of a wide range of diseases including cancers, hematological diseases, osteoporosis, autoimmune disorders and diabetes.

Suite 402, 6190 Agronomy Road
Vancouver, BC V6T 1Z3
Tel: 778-819-1622
Website

Ryan Vander Werff

Services Manager, Biomedical Research Centre, UBC

Researcher

Ryan Vander Werff is Single-Cell & Next-Gen Sequencing and Services Manager for the BRC-Seq at the Biomedical Research Centre of the University of British Columbia.

He received both his BSc and MSc from the University of California, San Diego in Molecular and Cellular Biology. During that time, his research focus was on Cancer Biology, looking at the mechanistic site of action for PTHrP’s growth inhibitory effects on Non Small Cell Lung Cancer. He went on to work for private labs focused on therapeutics, drug delivery, and diagnostics and worked with high throughput screening, laboratory automation, micro-fluidics, analytics, and most recently, next generation sequencing. With Sequenom, in La Jolla California, he sequenced fetal DNA through methylation-based filtering of maternal blood samples, setting up new assays via Illumina`s next generation sequencing, laboratory automation, and other technologies.

2222 Health Sciences Mall, UBC Vancouver, BC V6T 1Z3 ryanvw@brc.ubc.ca Website

Bruce Verchere

Professor, The University of British Columbia

Researcher

Dr. Bruce Verchere is Professor in the Departments of Pathology & Laboratory Medicine and Surgery at the University of British Columbia (UBC), head of the Diabetes Research Program at the Child & Family Research Institute (CFRI) at BC Children’s Hospital, and the Irving K Barber Chair in Diabetes Research.

Dr. Verchere's research focuses on the pancreatic islet and aims to understand how beta cell death and dysfunction arises in diabetes and following transplantation, with particular focus on islet amyloid and inflammation, with the goal of developing therapeutic approaches for enhancing beta cell survival and function in diabetes.

Dr. Verchere is chair of the CIHR Diabetes Obesity Lipid and Lipoprotein Disorders and JDRF Islet Biology & Transplantation Training and Innovative grant review panels, and a member of the national research council and national board of directors of the Canadian Diabetes Association. He has served on the editorial boards of Diabetes and the Canadian Journal of Diabetes and is currently on the editorial board of Endocrinology, and associate editor of the Bjournal Islets. In 2012, he received a Queen Elizabeth II Diamond Jubilee Medal for diabetes research and service.

950 West 28th Ave
Vancouver, BC V5Z 4H4
Tel: 604-875-2490 verchere@mail.ubc.ca
Website

Gilbert Walker

Professor, University of Toronto

Associate Scientific Director; Theme 3 Leader

Dr. Gilbert Walker is Professor of Chemistry at the University of Toronto and the Canada Research Chair (Tier 1) in Biointerfaces. Dr. Walker received his B.A in Chemistry and Mathematics from Bowdoin College in 1985, and his Ph.D from the University of Minnesota in 1991. In 1999, he joined the University of Pittsburgh as an assistant professor, and in 2005 became a Canada Research Chair Professor at the University of Toronto.

Dr. Walker works with polymers the size of one ten-thousandth of a human hair. He uses the unique ability of polymers to self-assemble, producing nanostructured materials with electromagnetic, mechanical, and physiological properties. His work in biomolecular interaction analysis is enabling more-timely cancer diagnosis and medical care and his aquatic polymer nanomaterials are being patented for greener aquaculture.

Chen Wang

Professor, University of Toronto

Collaborator

Dr. Wang is a hematopathologist and Head of the Division of Hematology, in the Department of Pathology and Laboratory Medicine of Mount Sinai Hospital. He is also an Associate Professor of Lab Medicine and Pathobiology at the University of Toronto.

His research is focused mainly on lymphocytic neoplasms. In collaboration with investigators at the University of Toronto, Dr. Wang developed Raman nanoparticles targeting leukemia cells and developed a flow cytometry method to assess this, and achieved triplex Raman nanoparticle labelling of leukemia cells.

Pathology & Lab Medicine
Mount Sinai Hospital
600 University Ave. Rm 602
Toronto ON  M5G 1X5
Tel: 416-586-4469
Chen.Wang@sinaihealthsystem.ca
Website

Ellen Wasan

Assistant Professor, University of Saskatchewan

Researcher

Dr. Ellen Wasan, B.S. Pharm., PhD., is an assistant professor in the College of Pharmacy and Nutrition, University of Saskatchewan. She is part of the Drug Discovery and Development Research (DDDRG) cluster in Health Sciences and teaches pathophysiology and pharmaceutics in the PharmD program in the College of Pharmacy and Nutrition.

Dr. Wasan’s research is focused on lipid-based drug delivery for poorly water-soluble drugs and macromolecules. She has extensive experience with liposomal and self-assembling systems for delivery of small molecules and nucleic acids. Current projects include development of oral chitosan polymeric nanoparticles for sustained release of immunosuppressants, lipidic formulations of adjuvants for nasal administration of human and veterinary vaccines, and topical agents for Raynaud’s phenomenon.

Dr. Wasan has over 40 publications, over 40 conference presentations and multiple drug delivery patents. She is an inventor of an oral formulation of Amphotericin B that is presently in Phase II clinical trials. She was the 2013 winner of the Gattefossé Lipid Drug Delivery Award of the American Association of Pharmaceutical Scientists and the 2011 Applied Research Award from the British Columbia Institute of Technology.

College of Pharmacy and Nutrition
107 Wiggins Rd.
D-Wing Health Sciences 3D01-17
University of Saskatchewan
Saskatoon, SK
S7N 5E5
Tel: 306-966-3202
ellen.wasan@usask.ca
Website

Kishor Wasan

Professor, University of Saskatchewan

Researcher

Dr. Wasan is Professor and former Dean (2014-2019) of the College of Pharmacy and Nutrition at the University of Saskatchewan.

His research interest is in in the area of lipid-based drug delivery and lipoprotein-drug interactions.

Dr. Wasan completed his Ph.D. at the University of Texas Medical Center's MD Anderson Cancer Center in Cellular and Molecular Pharmacology. He completed a postdoctoral fellowship in Cell Biology at the Cleveland Clinic and then joined the Faculty of Pharmaceutical Sciences at UBC until 2014.

Dr. Wasan has published over 200 peer-reviewed articles and 240 abstracts. He has received many awards and honours, including: a CIHR University-Industry Research Chair in Pharmaceutical Development (2003-2008); the title of University Distinguished Scholar (2004); an AAPS Award for Outstanding Research in Lipid-Based Drug Delivery (2007); an AFPC-Pfizer Research Career Award (2008); a CIHR/iCo Therapeutics Research Chair in Drug Delivery for Neglected Global Diseases (2009); induction into the Canadian Academy of Health Sciences (2010); and the Canadian Society of Pharmaceutical Sciences Leadership award for outstanding contributions to Pharmaceutical Sciences in Canada (2011).

E3326 Health Sciences
University of Saskatchewan
Tel: 306-966-6328
kishor.wasan@usask.ca
Website

Michael Weinfeld

Professor, University of Alberta

Researcher

Dr. Weinfeld is a Professor in the Division of Experimental Oncology in the Faculty of Medicine and Dentistry of the University of Alberta.

The focus of the research in his laboratory is the cellular response to chemical and radiation-induced stress. His team is particularly interested in DNA damage and repair, and cell death and survival.

4321 Cross Cancer Institute
Edmonton, AB
Tel: 780-432-8438
mweinfel@ualberta.ca
Website

Drew Weissman

Professor, University of Pennsylvania

Collaborator

Dr. Weissman is a Professor of Medicine in the Perelman School of Medicine of the University of Pennsylvania.

He is also an Attending Physician at the Philadelphia Veterans Administration Medical Center, a member of The American Association of Immunologists, and a member of the American Federation for Clinical Research.

His laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. He is currently developing new vaccine platforms, therapeutic proteins, and gene editing systems using nucleoside modified RNAs.

Dr. Weissman co-discovered the ability of modified nucleosides in RNA to suppress activation of innate immune sensors and increase the translation of messenger RNA (mRNA).

NMIN project involvement:

Collaborator: COVID-19 Therapeutics

410B Hill Pavilion 380 S University Ave. Philadelphia, PA 19104 USA Tel: 215-573-8491
Email
Website

Aaron Wheeler

Professor, University of Toronto

Researcher

Dr. Wheeler is Professor and Canada Research Chair of Bioanalytical Chemistry in the Institute of Biomedical Engineering at the University of Toronto.

His research is focused on the development of "lab-on-a-chip" techniques for high throughput proteomics and drug discovery. The lab-on-a-chip concept promises reduced reagent consumption and analysis time, the capacity to integrate multiple functions onto a single device, and the potential for high throughput analysis. Two paradigms have emerged for lab-on-a-chip: microchannels and digital microfluidics. The former technique relies on enclosed, interconnecting, micron-dimension channels; the latter facilitates transport of discrete droplets of fluid across the surface of an array of electrodes. His lab is developing hybrid methods that rely on the unique advantages of microchannels and digital microfluidics for high-throughput bioanalytical applications.

LM 629A – Lash Miller Chemical Laboratories, 80 St. George Street, Toronto, ON, M5S 3H6 Tel: 416-946-3864
Email Website

Lorne Whitehead

Professor, University of British Columbia

Researcher

Dr. Whitehead is a professor in the Department of Physics and Astronomy at the University of British Columbia, and he serves as the university’s Special Adviser on Entrepreneurship, Innovation and Research.

Dr. Whitehead studies the optical, electrical, and mechanical properties of micro-structured surfaces, a field in which he holds more than one hundred US patents and numerous international counterpart patents. His technology is used in many computer screens and televisions.

In addition to CLEARink, Dr. Whitehead has also helped to start five new companies, commercializing technologies that he developed in his UBC laboratory – Sonigistix, Brightside (purchased by Dolby Laboratories in 2007), Boreal Genomics, SunCentral and ELIX Wireless.

Previously, he has held a number of other administrative positions including Associate Dean, Dean pro tem, VP Academic & Provost and Leader of Education Innovation. In these roles he has often applied organizational innovation methods to the improvement of teaching and learning.

Since joining the UBC faculty in 1994,he has received more than 100 patents for innovations in building illumination and displays for computers, television and cinema.

Department of Physics & Astronomy
Vancouver Campus, UBC
325 – 6224 Agricultural Road
Vancouver, BC V6T 1Z1
Tel: 604-822-3075

Website

Dominik Witzigmann

Postdoctoral Fellow, The University of British Columbia

Researcher; Admin Lead, NanoCore

Dr. Witzigmann is a Postdoctoral Fellow at the University of British Columbia, is Administrative Lead for NMIN's NanoCore core facility, and currently serves on the board of the “Gene Delivery and Gene Editing Focus Group” of the Controlled Release Society (CRS).

Dr. Witzigmann's research is focused on targeted DNA therapeutics for the treatment of orphan monogenetic liver disorders and the development of lipid-based nanomedicines for the delivery of biomacromolecules. A key step in this development process is the investigation of nano-bio interactions at an organ and cellular level.

Karla Williams

Assistant Professor, University of British Columbia

Collaborator

Dr. Williams is Canada Research Chair in Oncology and an Assistant Professor in the Faculty of Pharmaceutical Sciences at UBC.

Dr. Williams aims to improve our ability to treat metastatic disease, and to develop new ways to detect disease early and identify individuals at high risk for cancer spread. She and her research team are studying invadopodia: tiny feet-like structures formed by cancer cells that help the cells move and grow. Understanding the role of invadopodia in cancer progression will validate them as drug targets.

Dr. Williams and her team are also using blood-based biomarkers to accurately detect breast cancer and identify high-risk individuals. Developing a non-invasive test that can discriminate between patients with non-life-threatening (indolent) disease and aggressive disease could lead to effective treatments for high-risk individuals while sparing those with indolent disease the toxic side effects of treatment.

5504 Pharmaceutical Sciences Building
Tel: 604-822-9915 karla.williams@ubc.ca Website

David Wishart

Professor, University of Alberta

Researcher

Dr. Wishart is a Professor in the Departments of Biological Sciences and Computing Science at the University of Alberta. He is also a co-director of the Nanobiology program at the NRC's National Institute for Nanotechnology (NINT).

His research interests span many areas including structural biology, bioinformatics, prion biology, nanobiology and metabolomics. From 2006-2009, Dr. Wishart led the "Human Metabolome Project" (HMP), a multi-university, multi-investigator project that catalogued all of the known metabolites in human tissues and biofluids. Using advanced methods in NMR spectroscopy, mass spectrometry, multi-dimensional chromatography and machine learning Dr. Wishart and his colleagues identified or found evidence for more than 8500 endogenous metabolites.

The methods and ideas developed for the HMP have helped lay the foundation for a number of clinical metabolomics projects currently being pursued in his lab. These include studies of several cancer biomarkers, identifying organ transplant biomarkers, exploring wound healing mechanisms, identifying early biomarkers of prion and prion-like diseases, and investigating biomarkers of common diseases in cows.

Dr. Wishart has active research programs in structural biology, nanobiology, synthetic biology, prion biology, bioinformatics and metabolomics. Some of his lab's most significant contributions have been in the area of protein chemical shift analysis and the prediction of protein structure.

Peter Zandstra

Professor, University of British Columbia

Collaborator

Dr. Zandstra is Professor & Director of School of Biomedical Engineering and Director of the Michael Smith Laboratories at the University of British Columbia. He is also Chief Science Officer of Centre for the Commercialization of Regenerative Medicine (CCRM). He holds an academic appointment as a Professor at the University of Toronto’s Institute of Biomaterials and Biomedical Engineering, and is the Canada Research Chair in Stem Cell Bioengineering.

Dr. Zandstra’s research focuses on understanding how complex communication networks between stem cells and their progeny influence self-renewal and differentiation, and how this information can be applied to the design of novel culture technologies capable of controlling cell fate.

His work integrates engineering and biological approaches and has contributed to the development of clinically and industrially relevant and academically recognized technologies based on the design of bioprocesses for the growth and differentiation of adult and embryonic stem cells. Direct applications of this work include tissue and cellular engineering, gene therapy, and organ transplantation.

Room 1116 Donnelly Centre
160 College Street
Toronto, ON
Tel: 416-978-8888
peter.zandstra@utoronto.ca
Website

Gang Zheng

Professor, University of Toronto

Researcher

Dr. Zheng is a Professor in the Department of Medical Biophysics, the Institute of Biomaterials and Biomedical Engineering, and the Leslie Dan Faculty of Pharmacy at the University of Toronto. He is also Associate Research Director of Princess Margaret Cancer Centre, Canada Research Chair in Cancer Nanomedicine (Tier 1), and Associate Editor of Bioconjugate Chemistry.

Dr. Zheng's research focuses on the development of novel technology platforms for molecular imaging, photodynamic therapy (PDT) and nanomedicine. His lab's main interest is to develop two new drug platforms to combat cancer: 1) light-activated intelligent molecules and 2) nature-inspired theranostic nanomedicine.

Dr. Zheng’s lab discovered porphysome nanotechnology (Nature Materials 2011), named one of the “top 10 cancer breakthroughs of 2011” by the Canadian Cancer Society. His lab also discovered that on exposure to low-frequency ultrasound, porphyrin microbubbles form nanoparticles that possess the same optical and therapeutic properties as the original microbubble, and can be used simultaneously for imaging and drug delivery (Nature Nano 2015).

MaRS Centre, Princess Margaret Cancer Research Tower 5th Floor Rm 354 101 College Street Toronto, ON
M5G 1L7
Tel: 416-581-7667 gang.zheng@uhnres.utoronto.ca Website

Yan Zhou

Research Scientist, University of Saskatchewan

Researcher

Dr. Zhou is Adjunct Professor in the Department of Veterinary Microbiolo, and a Scientist and Project Leader (influenza) at the university's Vaccine and Infectious Disease Organization (VIDO).

Her research expertise includes molecular biology of influenza virus, virus induced signal transduction, viral pathogenesis and vaccine development.

University of Saskatchewan
120 Veterinary Road
Saskatoon, SK, S7N 5E3
Tel: 306-966-7716
yan.zhou@usask.ca
Website

Shan Zou

Sr. Research Officer, National Research Council

Researcher

Dr. Zou is a Senior Research Officer and Team Leader for Nanoscale Measurement at the Metrology Research Centre of the National Research Council Canada. She is also an Adjunct Professor in the Department of Chemistry at the University of Carleton.

Her research focuses on the development of nanoscale standards and measurement methods that underpin applications of nanoscience; and the development of integrated multimodal techniques for characterization of nanomaterials and quantitative detection of cancer cells and cellular mechanical responses to drug treatments. Recently, she has been working on the reference material development of boron nitride nanotubes and cytotoxicity of nanomaterials.

Dr. Zou has expertise in nanomechanical characterization; cytotoxicity measurements of nanomaterials; and material and surface characterization. She seeks to contribute to a greater understanding of the effects of nanomaterials on the environment and living systems, and to promote the safe and responsible use of nanotechnology tools and nanomaterials.

100 Sussex Drive
Building Sussex, Room 1095
Ottawa, Ontario K1A 0R6
Tel: 613-949-9675
Shan.Zou@nrc-cnrc.gc.ca
Website